Abstract: A method of ICP-MS with octopole reaction system (ORS) was used for determination of As, Cr, Cu, Mn, Se, Pb, Hg, Cd and Co in food flavour. The pretreatment conditions were improved and the instrument operating parameters were optimized. The interference of polyatomic ions was effectively eliminated by using ORS combined with helium pattern technology. The linear ranges of the elements was within 10 μg·L-1, correlation coefficients over 0.995.The detection limits (3s) were in the range of 0.000 6-0.016 μg·L-1. Recovery rates measured by standard addition method were in the range of 90.0%-114%, with RSD (n=6) were less than 5%. The method was used to analyze standard substances, giving results consistent with the certified values.