Abstract: UPLC-MS/MS was applied to the determination of 7 illegally added sedative drugs in health foods with solid phase extraction. The health-care food sample was extracted with methanol, and after high-speed centrifugation, the supernatant was taken and purified on Oasis MCX SPE solumn. Zorbax-SB-C18 chromatographic column was used as stationary phase, and mixtures of 0.1% (φ) formic acid solution and acetonitrile in various ratios were used as mobile phase in gradient elution. ESI+ and multi-reaction monitoring were adopted in MS/MS. Linear relationships between values of peak area and mass concentration of the 7 compounds were kept in the same range of 0.10-30.0 μg·L-1, with lower limits of determination (10S/N) in the range of 0.1-2.1 μg·kg-1. Tests for recovery and precision were made by standard addition method at the concentration levels of 0.30, 3.0, 10.0 μg·L-1, giving values of recovery and RSD′s (n=6) in the ranges of 76.7%-104% and 2.1%-9.8% respectively.