Abstract: Six solutions containing various solutes, including 95% (φ) ethanol solution were selected as simulated media, and 4,4′-dihydroxy-biphenyl (BPH) and 4,4′-dichloro-diphenyl sulfone (DCPS), which were possibly migrated from the food-packaging materials or containers during their contaction with these media, were determined separately by HPLC. Waters Xbridge-liquid chromatographic column was used as stationary phase, while mixtures of methanol and water in various ratios were used as mobile phase in gradient elution. UV-detection with DAD at the wavelength of 254 nm was adopted. As shown by the testing results, value of lower limit of determination (10S/N) found for the method was 0.015 mg·kg-1. Recovery was tested by standard addition method at 3 concentration levels, giving values of recovery in the range of 89.0%-106%, and values of RSD′s (n=6) found were all less than 4%. Amounts of migration of the 2 above mentioned compounds in various simulated media in contact with a PPSU feeding bottle as the food container were tested by the proposed method, but none of the 2 compounds was detected.