Abstract: The sample (0.500 0 g) of water soluble raw pharmaceuticals was dissolved with 50 mL HNO₃ (2+98) solution. ICP-MS was applied to the determination of trace amount of nickel in the sample solution. Rh was used as internal standard. Kinetic energy discrimination mode was adopted for removing the interference based on the kinetic energy discrimination effects. Linearity range of nickel was found in the range within 5.0 μg·L^-1 with detection limit (3s) of 0.002 μg·L^-1. Values of recovery found by standard addition method were in the range of 96.0%-97.0%, and values of RSD (n=6) found was less than 5.0%.