Abstract: The sample was diluted with pH 4.0 of Na₂EDTA-Mcllvaine buffer solution, and pesticides and antibiotics in the sample were extracted with a mixture of acetic acid-acetonitrile (1+19), and the extract was stratified by salting-out agents. The supernatant was cleaned up with purification pipe filled with magnetic C₁₈ and PSA. Luna C₁₈ column was used as stationary phase, and a mixture of 0.1% (φ) formic acid solution and acetonitrile in various ratios as mobile phase in gradient elution. ESI⁺ and MRM were adopted in MS. Linear relationships between values of peak area and mass concentration of 30 compounds were found in definite ranges, with detection limits (3S/N) in the range of 0.3-4.1 μg·kg^-1. Test for recovery was made by standard addition method, giving results in the range of 71.1%-116%, with RSDs (n=5) ranged from 0.80% to 21%.