Abstract: UHPLC-MS was applied to the determination of 7 lignans, i.e. Schisantherrin A, Schisanhenol, Deoxyschisandrin, Schisandrin B, Schisandrin C, Schisandrin and Schisandrol B in Schisandra vinegar products. The sample (0.200 0 g) was extracted ultrasonically with methanol (10 mL) for 30 min. ACQUITY UPLC BEH C₁₈ chromatographic column was used as stationary phase, and the mixture of acetonitrile and 0.1% (φ) formic acid solution mixed in different ratios was used as mobile phase in gradient elution. ESI⁺ and the selected ion monitoring mode were adopted in MS. Linear relationships between values of peak area and mass concentration of the 7 lignans were kept in definite ranges. Detection limits (3S/N) of the method ranged from 0.001 to 0.050 mg·L^-1. Precision of the method was tested at the concentration level of 6.0 mg·L^-1 of the 7 lignans mixed standard solution for 6 determinations, values of RSDs found were in the range of 1.2%-3.5%. The proposed method was applied to the analysis of samples of Schisandra vinegar products, giving values of recovery in the range of 85.4%-99.3%.