Abstract: Vegetable was collected from the growing area, washed with water, cut into segments and sampled by quartering; the sample was then crushed and 1.000 g of the crushed sample was treated with 7 mL of HNO₃ in a constant temperature digester at 120℃ for 30 min. The digested solution was then removed to a microwave digester to have a further digestion of the sample under 1 000 W for 25 min. After cooling, the digested solution was diluted with HNO₃ (2+98) solution and its volume was made up to 25.0 mL, which was used for ICP-MS determination of Cr, Cd, As, Pb and Hg. Isotopes having high relative abundance (i.e. ⁵²Cr, ¹¹¹Cd, ⁷⁵As, ²⁰⁸Pb and ²⁰²Hg) were selected as the species in the respective determinations to overcome effects of isobaric interferences to a definite extent. Besides, elements of C, H, O, N, Cl, S and Mo, which were existed in vegetables very often, might form polyatomic ions with Ar in the carrier gas, making interferences of polyatomic ions. DRC mode with gaseous NH₃ as reactant in the MS determinations of ¹¹¹Cd, ⁵²Cr and ⁷⁵As was adopted to eliminate such interferences. STD mode was applied to the MS determinations of ²⁰²Hg and ²⁰⁸Pb, since no polyatomic ion interference was encountered in these cases. Moreover, to overcome some new interferences arised in the DRC mode of determinations, setting up to RP_q values was found to be effective. It was shown by the testing results, linear relationships between values of intensities of analytical signals and the mass concentrations of the 5 related elements were found in the definite ranges, with their detection limits (3s/k) ranging from 0.2 to 3.2 μg·kg^-1. Recovery was tested by standard addition method, giving results of recovery in the range from 92.9% to 108%, and RSDs (n=5) in the range of 1.2%-5.8%.