Abstract: The river water sample (500 mL) was collected and 50.0 μg·L^-1 mixed solution of internal standard (100 μL) were added. Enrichment and purification were processed by the instrument of automated solid phase extraction with ENVI^TM-18 solid phase extraction column. The collected eluate was evaporated to near dryness by N₂-blowing at 40℃ in the water bath and then made up to 1.0 mL with acetonitrile (1+1) solution. UHPLC-MS/MS was applied to the simultaneous determination of 8 phenolic endocrine disrupting chemicals in the solution. HSS T3 chromatographic column was used as stationary phase, and the mixture of 0.1% (mass fraction) ammonia and acetonitrile mixed in different ratios was used as mobile phase in gradient elution. ESI^- and multi-reactions monitor mode were adopted in MS/MS. Internal standard method was used for quantitative.Linearity ranges of the 8 phenolic endocrine disrupting chemicals were found in the same range of 0.10-40.00 μg·L^-1 with detection limits (3S/N) in the range of 0.008-0.096 ng·L^-1. The proposed method was applied to the analysis of the water sample of Minjiang River, giving values of recovery found by standard addition method and RSDs (n=6) of recovery amounts in the ranges of 80.0%-91.8% and 2.9%-12% respectively.