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    顶空-气相色谱-离子迁移谱法快速测定化妆品中5种香料的含量

    Rapid Determination of Five Fragrances in Cosmetics by Headspace-Gas Chromatography-Ion Mobility Spectrometry

    • 摘要: 提出了顶空-气相色谱-离子迁移谱法快速测定化妆品中丙烯酸乙酯、苧烯、反式-2-庚烯醛、芳樟醇、柠檬醛等5种香料含量的方法。取化妆品样品或用水稀释后的化妆品样品,在80 ℃下孵化20 min,顶空进样,在正离子模式,迁移管线性电压400 V·cm-1,迁移管温度45 ℃,迁移气流量150 mL·min-1的条件下测定样品中丙烯酸乙酯、苧烯、反式-2-庚烯醛、芳樟醇、柠檬醛等5种香料的含量。结果表明,5种香料标准曲线的线性范围为0.1~5.0 mg·L-1,检出限(3S/N)为0.02~0.05 mg·L-1。方法用于分析8批化妆品,检出苧烯和芳樟醇两种香料,检出量为0.005~352 μg·g-1,与常规气相色谱-串联质谱法检测结果进行对比,相对偏差为-8.6%~10%。

       

      Abstract: A method was proposed for the rapid determination of five fragrances, including ethyl acrylate, limonene, trans-2-heptenal, linalool and citral, in cosmetics by headspace-gas chromatography-ion mobility spectrometry. The cosmetic sample or the cosmetic sample diluted with water was taken, incubated at 80 ℃ for 20 min, and injected into headspace. The five fragrances were determined with mobility tube linear voltage of 400 V·cm-1, mobility tube temperature of 45 ℃ and mobility gas flow rate of 150 mL·min-1 in positive ion mode. As shown by the results, the linear range of the standard curve of the five fragrances was 0.1-5.0 mg·L-1, and detection limits (3S/N) in the range of 0.02-0.05 mg·L-1. This method was used to analyze 8 batches of cosmetics, and limonene and linalool were detected, with the detection amounts of 0.005-352 μg·g-1. Compared with the results of conventional gas chromatography-tandem mass spectrometry, the relative deviation was in the range of -8.6% -10%.

       

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