Abstract: The Os Draconis sample powder (0.1 g) was taken and placed in a polytetrafluoroethylene digestion tube, and 5 mL of nitric acid was added. The mixture was sealed and thoroughly mixed, and digested by microwave at 220 ℃ for 30 min. After cooling down, a small amount of water was added to rinse, and the solution was transferred into a 50 mL-volumetric flask and made its volume up to 50 mL with water. The solution was centrifuged, and P and S elements in the supernatant were determined by inductively coupled plasma atomic emission spectrometry (ICP-AES), and the remaining 53 elements were determined by inductively coupled plasma mass spectrometry (ICP-MS) with internal standard method. The 51 elements detected in 37 batches of Os Draconis samples were subjected to the correlation analysis using the IBM SPSS Statistics 26.0 software, and the SIMCA14.1 software was used for identification the sources of Os Draconis and elements that caused the differences. As shown by the results, linear relationships between the corresponding signal intensities and mass concentrations of P and S elements were kept in definite ranges, and linear relationships between the ratios of the corresponding signal intensity to the internal standard signal intensity and mass concentrations of the remaining 53 elements were kept in definite ranges, with detection limits (3s) in the range of 0.000 2-7.916 mg·kg⁻¹. Test for precision was conducted on actual Os Draconis sample solutions, with RSDs (n=6) of the determined values less than 13%. Test for recovery was made by the standard addition method, giving results in the range of 85.0%-114%. This method was applied to analysis of 37 batches of actual Os Draconis samples, and it was shown by the results that the contents of Ca and P elements in Os Draconis were the highest, and there was a significant positive correlation between them. The contents of Ba, Na, Mg, S, Al, Sr, and Fe elements were varied greatly among different batches, and there were varying degrees of correlation between them. The contents of heavy metals and harmful elements were relatively lower. Te, Os, Ru, and Pt elements were not detected. U, Sr, Mg, and rare earth elements might be characteristic elements that caused the differences among Os Draconis from different sources.