Abstract: A study mentioned by the title was conducted to address the issue of low accuracy in the determination of element content in high loss-on-ignition manganese ore using wavelength dispersive X-ray fluorescence spectrometry. The sample was pre-dried at 105 ℃ for 2 h, and then burned at 1 000 ℃ to a constant weight. The loss-on-ignition was calculated based on the difference in sample mass before and after burning. After cooling, the sample was ground to the powder with particle size of no more than 74 μm, and 10 g of the powder was taken, and pressed into sample pieces with diameter of 34 mm for determination by wavelength dispersive X-ray fluorescence spectrometer, eliminating spectral line overlap interference and matrix interference with basic parameter method, and correcting the determination results with loss-on-ignition. As found by results, linear relationships between values of the fluorescence intensity of the 11 major and minor element oxides in a series of national certified reference materials for manganese ore and certified values corrected by ignition-on-loss were kept in definite ranges, with detection limits in the range of 0.001 5%-0.008 4%. The proposed method was used for the analysis of samples and reference materials with different concentration gradients, and RSDs (n=7) of determined values of MnO, SiO₂, Fe₂O₃, CaO, BaO, TiO₂, and K₂O were within 10%, while RSDs (n=7) of determined values of Al₂O₃, MgO, Na₂O, and P₂O₅ were within 20%. The determined values of 11 target element oxides were consistent with those given by the wavelength dispersive X-ray fluorescence spectrometry with fusion sampling in GB/T 24519—2009.