Abstract: To achieve rapid and accurate determination of multiple perfluoroalkyl compounds （PFCs） in batches of cosmetics containing marine bioextracts, the study mentioned by the title was conducted. The 0.20 g of sample was taken, and approximately 5 mL of methanol was added. The mixture was mixed well by vortex, and ultrasonically extracted for 15 min, and its volume was made up to 10 mL with methanol. After centrifuging for 5 min at 10 ℃, the supernatant was passed through filtration-type HLB solid phase extraction column. The eluate was collected, and passed through a 0.22 μm organic phase membrane, and the filtrate was introduced into ultra-high performance liquid chromatograph-tandem mass spectrometer. The 8 PFCs were separated on CNW Athena-C₁₈ column by gradient elution with the mobile phase system consisting of methanol and 1 mmol·L⁻¹ ammonium acetate solution. Mass spectrometric analysis was performed in negative electrospray ionization mode with multiple reaction monitoring mode, and quantification was carried out using the matrix matched method. It was shown that linear relationships between the mass concentrations and mass spectrometry response values of the 8 PFCs were kept in the range of 0.2−20.0 μg·L⁻¹, with lower limits of determination （10S/N） of 0.010 μg·g⁻¹. Spike recovery tests were performed on 3 matrix types （aqueous solutions, emulsions, and creams）, giving recoveries of the 8 PFCs in the range of 79.4%−118%, and RSDs （n=6） of the determined values ranged from 0.10% to 8.6%. The proposed method was applied to the analysis of 80 batches of actual samples. Perfluorooctanesulfonic acid and perfluorodecanesulfonic acid （PFDS） in one emulsion sample were detected with detection amounts of 0.65, 0.55 μg·g⁻¹, and PFDS was detected in one cream sample with detection amount of 0.047 μg·g⁻¹.