Abstract: A method of HPLC-ICP-MS for the determination of iodate and iodide in drinking water was proposed. Dionex IonPac AS14 anion chromagraphic column and AG14 guard column and 50 mmol·L-1 ammonium carbonate (adjusted to pH 9.9 with aq. ammonia) as mobile phase were used for separation of iodate and iodide. The eluates were used for ICP-MS determination, with linearity ranges between 0.20 to 300 μg·L-1 for both iodate and iodide. Values of detection limit (3S/N) found were 0.09 μg·L-1 for iodate and 0.13 μg·L-1 for iodide. Tests for recovery and precision were made by standard addition method at 2 different concentration levels, the results obtained were as follows: ① for iodate, recovery: 100.5% to 113.0%, RSD′s (n=8): 1.2% to 2.8%; ② for iodide, recovery: 101.9% to 110.7%, RSD′s (n=8): 1.3% to 2.0%.