Abstract: A method of XRFS for determination of major elements and elements of control contents in IC10 alloy was proposed.The elements of control contents were determined by virtual valuation method;and the major elements were determined by the basic parameter method (i.e.the single-point comparative standard).It was found that values of RSD′s (n=11) of major elements and elements of control contents were less than 0.35% and 2.0%,respectively.