Abstract: A review of the recent advances of multi-class,multi-residue analytical method for screening of low-weight organic contaminants in food of animal origin was presented,including extraction methods,such as liquid-liquid extraction,accelerated solvent extraction,dispersive solid phase extraction,et al,purification methods,such as liquid-liquid extraction,freezing,solid phase dispersion extraction,solid-phase extraction,et al,and instrumental analysis methods,such as LC,MS,LC-MS,et al. Future perspectives and potential directions were also outlined (64 ref. cited).