Abstract: The Levenberg-Marquardt BP-ANN algorithm was applied to the simultaneous spectrophotometric determination of acetaminophen,guaifenesin,caffeine and chlorphenamine maleate in colds-curing durgs,to overcome overlapping of absorption spectra of the 4 components.Optimum conditions of spectrophotometry and parameters of the network were tested and determined.Special features of the algorithm proposed were its rapidity of training and accuracy of result prediction.The 4 components in sample were determined directly without preliminary separations.Results of recovery test obtained were in the range of 99.0%-110.4%.