单扫描示波极谱法测定非那雄胺

Determination of Finasteride by Single-Sweeping Oscillopolarography

摘要: 在0.01 mol·L-1 HCl-2.5×10-5mol·L-1十二烷基三甲基氯化铵-水-乙醇溶液(21+4)底液中,采用单扫描示波极谱法测定,非那雄胺在-1.27 V(vs.SCE)处有一灵敏的极谱还原波.二阶导数峰电流I″p与非那雄胺浓度在1.0~10.0 mg·L-1范围内呈线性关系,相关系数为0.999 6(n=6),检出限为0.2 mg·L-1.连续11次平行测定2.0 mg·L-1非那雄胺还原波峰电流,相对标准偏差为1.3%.此方法用于片剂中非那雄胺含量的测定,其回收率在99.7%~105.2%之间.

Abstract: In a mixed base solution of 0.01 mol·L-1 HCl and 2.5×10-5mol·L-1 dodecyl-trimethyl ammonium chloride in aqueous ethanol solution (H2O+C2H5OH=21+4),a sensitive reduction wave was given by finasteride with its peak potential at -1.27 V (vs.SCE) by single sweeping oscillopolarography.Linear relationship between the 2nd derivative of peak current (I″p) of the reduction wave and the concentration of finasteride was obtained in the range of 1.0-10.0 mg of finasteride per L of solution (r=0.999 6),with a detection limit of 0.2 mg·L-1.The RSD′s found when tested at the concentration level of 2.0 mg·L-1 was 1.3% (n=11).The proposed method has been applied to the analysis of finasteride tablet samples,giving recoveries in the range of 99.7%-105.2%.