Determination of Migration of Three Phenolic Endocrine Disruptors from Food Processing Appliances by Solid-Phase Extraction Combined with High Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry

10% (φ, the same below) ethanol solution was selected as the food simulant for the coffee maker and the tea maker, and 20% ethanol solution was selected as the food simulant for the soybean milk maker. According to the actual conditions of use, the working status of food processing appliances were set and migration test was carried out under the follow conditions:food simulant of 500 mL, temperature of 100℃, migration time of 1 h. After the migration test, the food simulant was allowed to stand and cool to room temperature, and then bisphenol A, 4-n-octylphenol and 4-n-nonylphenol in the solution were enriched using an Oasis HLB solid-phase extraction column and eluted with methanol. The three phenolic compounds in the eluent were separated on a Waters XBridge C₁₈ chromatographic column (2.1 mm×150 mm, 3.5 μm), with methanol and 0.1% ammonia solution (φ) as mobile phases for gradient elution. Multiple reaction monitoring mode was used for MS/MS analysis. Linear relationships were found between peak areas and mass concentraitons of the three phenolic compounds in definite ranges, with detection limits (3S/N) in the range of 0.001 3-0.002 5 mg·dm^-2. Values of recovery obtained by standard addition method ranged from 84.6% to 107% and RSDs (n=6) ranged from 3.0% to 9.1%.