ICP-MS Determination of Residual Amount of Palladium in Zytiga Bulk Drugs

The sample (0.500 0 g) of Zytiga bulk drug was dissolved with 5.0 mL of HNO₃ and 1.0 mL of HClO₄ with microwave digestion. The above solution was heated to near dryness, and then the digestion solution was diluted to 25 mL with water. ICP-MS was applied to the determination of residual amount of palladium in the solution. He tuned mode with collision pool was used, and ¹⁰⁵Pd with higher abundance and stronger anti-interference was used as isotope. ¹¹⁵In was used as internal standard. Linearity range of palladium was found in the range within 80.0 μg·L^-1 with detection limit (3.3s/k) of 0.020 8 μg·L^-1. The proposed method was applied to the analysis of the sample of Zytiga bulk drug, giving value of RSD (n=6) of 1.2%. Values of recovery found by standard addition method were in the range of 94.0%-100%.