Properties of Novel Binaphthol Derivative Chiral Stationary Phase

3,3'-Di-p-benzoic acid-2,2'-dimethoxy-1,1'-bisnaphthalene was synthesized with R-dinaphthol as a chiral source, then it was bonded to 3-aminopropyl silica gel to prepare chiral stationary phase. This binaphthol derivative chiral stationary phase was characterized by SEM, IR and elemental analysis. The properties of resolution of chiral drugs and positional isomers on binaphthol derivative chiral stationary phase were investigated by HPLC, with n-hexane-isopropanol solution used as mobile phase and wavelength of UV detection at 254 nm. As shown by the results, 5 chiral compounds and 8 positional isomers were separated in different degree.