Application Progress in Detection of Ochratoxin A by Optical Aptamer Sensors

Ochratoxin A (OTA) is a fungal toxin produced by Aspergillus and Penicillium, which has strong hepatic and renal toxicity and hazard of teratogenic and carcinogenic. OTA is widely found in grains and foods (including wheat, corn, coffee and grapes), seriously damaging human health. Due to the seriousness of hazard and its wide distribution, it is important to develop convenient, fast and highly sensitive OTA detection technology. The current methods for detecting OTA include thin layer chromatography, high performance liquid chromatography, fluorescence analysis and enzyme-linked immunosorbent assay, which are usually costly, and complicated and time-consuming to operate. Optical aptamer sensors have rapidly developed and shown great advantages in the field of OTA detection, thus the principle, performance and relevant applications in 2011-2023 of fluorescence (including marked and unmarked types), colorimetric, chemiluminescence, and other (including surface plasmon resonance, lateral chromatography and surface enhanced Raman scattering types) optical aptamer sensors for OTA detection were reviewed, and summary of the problems faced by the above method and prospects for future development trends were provided (81 ref. cited).