Electrochemical Behavior of Aciclovir at Activated Glassy Carbon Electrode and Its Analytical Application

Electrochemical behavior of the anti-virus drug.Aciclovir (ACLV) at activated glassy carbon electrode (GCE) was studied by cyclic voltammetry and differential pulse stripping voltammetry.The GCE was activated in 1.0 mol·L-1 NaOH solution for 500 s by cyclic voltammetry at the potential range from 0.5-1.5 V.In a B-R buffer solution of pH 3.0,a well-defined oxidative peak of ACLV was observed at 1.25 V (vs.Ag/AgCl) with the activated electrode.Linear relationship between values of peak current (Ip) and concentration of ACLV was found in the range of 5.0×10-7-1.0×10-5mol·L-1,and the detection limit (3S/N) found was 1.7×10-7mol·L-1,which is about 12 times lower than the detection limit of the method using the bare GCE.The proposed method was used to determined ACLV content in a tablet sample,giving results in conformity with the results found by spectrophotometry.