Preparation and Application of a Potentiometric Sensor for Determination of Sibutramine Hydrochloride

By using the ion association complex formed between sibutramine hydrochloride and sodium tetraphenylborate as electroactive substance, and polyvinyl chloride (PVC) membrane as carrier, a potentiometric sensor was prepared, showing selective potential response toward sibutramine hydrochloride in the range of 1.0×10-6-1.0×10-1mol·L-1 with detection limit (3S/N) of 5.62×10-7mol·L-1, and slope of 50 mV·pc-1 in a solution of pH 5 at 26 ℃. Recovery of the method was tested by standard addition method on the base of samples of sibutramine hydrochloride drug, results of recovery found were in the range of 97.3%-100.2% with RSD′s (n=5) less than 2%.