FI-Chemiluminescence Determination of Ranitidine Hydrochloride in Reversed Micellar Nano-microreaction Medium (RMNRM)

An ion-association complex was formed between RNTD+ and AuCl-4 in an acidic medium of 0.05 mol·L-1 HCl,which was then extracted with 5 mL of n-octanol.The extract was injected into the FI-analyzer and carried over to the confluence point by the carrying solvent n-octanol to mix with the reversed micellar nanoreactant,which is a mixed solution of luminol and CTMAC in mixed solvent of n-octanol and cyclohexane.The mixture containing the reactants ion association complex RNTD+·AuCl-4 and luminol in the presence of CTMAC,was flowed into the reaction coil,where the CL reaction between the liberated AuCl-4 and luminol in the RMNRM was completed and the CL-intensity measured,and RNTD was determined indirectly.Linear reactionship between values of CL-intensity and concentration of RNTD was obtained in the range of 0.001-10 mg·L-1,with a detection limit (3s) of 0.03 μg·L-1.The proposed method has been applied to the determination of RNTD in tablets and injections,as well as in samples urine and plasma,giving results in consistency with the results obtained by pharmacopoeia method.