MS/MS Direct Determination of 1,4-Dioxane in Daily Chemo-necessities with Surface Desorption Atmospheric Pressure Chemical Ionization

Surface desorption atmospheric pressure chemical ionization-tandem mass spectrometry (SDAPCI-MS/MS) was applied to the direct and rapid determination of 1,4-dioxane in daily chemo-necessities, without sample preparation and pretreatment. In the MS/MS analysis, SDAPCI was used as ion source, and positive electrospray ionization as well as collision induced dissociation reaction monitoring mode was taken for qualitative and quantitative analysis. The characteristic peaks of the fragments of 1,4-dioxane at m/z 72, 45, 61 and 32 respectively were confirmed. Linearity range of 1,4-dioxane was kept in the range of 0.1-1 000 mg·L-1, with value of detection limit (3σ) of 7.8×10-3mg·L-1. The proposed method was used in the analysis of samples of hand lotion and shampoo, giving values of recovery and RSD′s in ranges of 84.7%-98.5% and 10%-18% respectively.