FI-Chemiluminescence Determination of Levonorgestrol in Its Tablets

In a dil.H2SO4 medium,weak chemiluminescence (CL) was produced by the reaction between KMnO4 and Na2SO3,and was enhanced to a great extent by the presence of levonorgestrol (abbreviated as LNGT).It was found that in the concentration ranges of 0.01 to 0.5 mg·L-1 and 0.5 to 5.0 mg·L-1,linear relationships between the magnitude of increase in CL intensity and concentration of LNGT were obtained.Based on these facts,a new FI-CL method for determination of LNGT in its tablets was proposed with a detection limit (S/N=3) of 6.4 μg·L-1.Precision of the method was tested at the concentration level of 0.1 mg·L-1 of LNGT with 11 determinations,giving value of RSD of 4.3%.