Linear Scanning Polarographic Determination of Simvastatin

It was found that in a PBS of pH 6.88 and by the linear scanning polarography, a sensitive adsorption wave of simvastatin was observed at the potential of -1.188 V (vs.SCE). Linear relationship between values of 1st derivative of the peak current and mass concentration of simvastatin was obtained in the range of 0.01-5.0 mg·L-1 with detection limit (3S/N) of 7.0 μg·L-1. Precision was tested with standard solution of simvastatin of 5.0 mg·L-1 for 6 determinations, value of RSD (n=6) found was 0.53%. The proposed method has been used in the determination of content of simvastatin in its tablets.