NIR Spectrometric Analysis of Gliclazide Tablets

Chemometrics was applied to data treatment in the rapid NIRS analysis of gliclazide tablets. The method of partial least square (PLS) was used in the establishment of analytical mathematical model. Through spectral pretreatment and step-by-step optimization, and the following parameters were obtained: correlation coefficient of the analytical model was 0.991, RMSECV was 0.641, RMSEP was 0.980 and main factor 4. The analytical model was tested by analysis of 15 typical samples by the present method. Relative error of the results obtained were in the range of -2.04%-3.52%.