Voltammetric Determination of Acetaminophen Using Carbon Paste Modified Electrode Doped with Selenium

Carbon paste modified electrode doped with selenium was prepared by cyclic voltammetry, and the electrochemical behavior of acetaminophen (ACOP) at this electrode was studied by cyclic voltammetry and differential pulse voltammetry. A cyclic voltammetric method for the determination of ACOP with carbon paste modified electrode doped with selenium was established. In 0.1 mol·L-1 HOAc-NaOAc buffer solution of pH 4.6, a sensitive oxidation peak of ACOP at +0.61 V (vs.SCE) was observed. Linear relationship between values of oxidation peak current and concentration of ACOP was kept in the range of 6.0×10-7-1.5×10-4mol·L-1 with detection limit (3s/k) of 2.8×10-7mol·L-1. The proposed method was applied to the analysis of tablet samples, giving results in consistency with the values obtained by pharmacopoeia method with RSD′s (n=5) in the range of 2.1%-2.5%.