Simultaneous Determination of Propranolol Hydrochloride and Flunarizine Hydrochloride by Synchronous Fluorimetry

Synchronous fluorimetry was proposed for the simultaneous determination of propranolol hydrochloride and flunarizine hydrochloride. It was found that satisfactory results were obtained by setting at the wavelength 296 nm for determination of propranolol hydrochloride, 263 nm for flunarizine hydrochloride, and wavelength difference (Δλ) 50 nm in the synchronous fluorescence measurements. Linear relationships between values of fluorescence intensity and mass concentration were found in the ranges of 1.2×10-6-2.8×10-3g·L-1 for propranolol hydrochloride and 2.0×10-5-3.6×10-3g·L-1 for and flunarizine hydrochloride, with detection limits (3S/N) of 3.2×10-7 and 6.8×10-6g·L-1 respectively. The proposed method was used for determination of propranolol hydrochloride and flunarizine hydrochloride in mixed samples, giving values of recovery in the ranges of 97.5%-101.1% for propranolol hydrochloride and 97.5%-101.7% for flunarizine hydrochloride.