Spectrophotometric Determination of Metoclopramide Based on Its Charge Transfer Reaction with Chloranilic Acid

It was found that in an ethanol medium,a charge transfer complex with mole ratio of 1 to 1 was formed by the reaction between metoclopramide and chloranilic acid,showing its absorption maximum at the wavelength of 532 nm. Apparent molar absorptivity of 1.21×103L·mol-1·cm-1 was found,and Lambert. Beer′s law was kept in the range of 10.0-300.0 mg·L-1 for metoclopramide. Precision of the method was tested with standard solution of metoclopromide for 6 determinations,giving value of RSD 0.58%. Two samples of metoclopromide from different batches were analyzed by the proposed method giving results in consistency with results found by the pharmacopeia method and recovery was tested by standard addition method with these samples as matrixes,the values of average recovery found were in the range of 97.8%-101.5%.