Separation of Enantiomers of 6 Alkamine Drugs on 1-Napthalene Vancomycin Chiral Stationary Phase

Enantiomers of 6 alkamine drugs, including propranolol, bisoprolol, atenolol, metoprolol, soatlol and salbutamol, were separated on the self-made 1-napthalene vancomycin chiral stationary phase. Influential factors to the separation, including kinds and concentration of acid and alkali as additive, and chemical structure of solute, were studied, and the mechanism of recognition of chirality was discussed. It was found that enantiomers of 6 alkamine drugs were completely separated on the 1-napthalene vancomycin chiral stationary phase. The separation factors were attained to 1.16, 1.36, 1.15, 1.10, 1.18 and 1.16 for the 6 alkamine drugs respectively, when the amounts of the additives glacial acetic acid and triethylamine in the mobile phase were same as (φ %) 0.001%.