Page 137 - 理化检验-化学分册2024年第十二期

覃 勇，等：不饱和脂肪酸结构表征的质谱分析方法的研究进展

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Research Progress of Mass Spectrometry Analysis Methods for Structural
Characterization of Unsaturated Fatty Acids

QIN Yong , WANG Mindan , LIU Li , FENG Chenguo , CHEN Xiuping 1,2* , ZHANG Fang 1,2
1
1,2
1
1
(1. The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of
Traditional Chinese Medicine, Shanghai 201203, China; 2. Guangxi Institute for Food and Drug Control, Nanning 530021, China)
Abstract: Unsaturated fatty acids (UFA) exist widely in organisms, participate in many life activities and play important
physiological functions. However, due to the poor functional groups and the existence of a large number of isomers, the structural
identification and detailed analysis of UFA face many challenges. Mass spectrometry (MS) analysis has become the main
method for the detection of UFA because of its high selectivity, good sensitivity, and the ability to provide molecular mass and
fragmentation information. The MS analysis methods for structural characterization of UFA were summarized from the 3 ways of
the fat carbon chain analysis, double bonds position analysis and cis-trans isomerism analysis, and the development trend of MS
analysis methods was prospected (101 ref. cited).
Keywords: unsaturated fatty acid; structural characterization; mass spectrometry; research progress

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