Page 138 - 理化检验-化学分册2025年第三期

刘天宇，等：衍生化在脂肪酸质谱分析中的应用研究进展

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Research Progress on Application of Derivatization in Mass Spectrometry
Analysis of Fatty Acid

LIU Tianyu, ZHANG Chenglong, YANG Ruiqin , QIN Ge
*
(School of Criminal Investigation, People's Public Security University of China, Beijing 100038, China)
Abstract: With its high sensitivity and selectivity, mass spectrometry has become an essential tool for analyzing fatty acids.
Due to the low ionization efficiency of fatty acids, direct detection by mass spectrometry has low sensitivity and often requires
the derivatization treatment. The common mass spectrometry platforms, including gas chromatography-mass spectrometry (GC-
MS), liquid chromatography-mass spectrometry (LC-MS), capillary electrophoresis-mass spectrometry (CE-MS), and mass
spectrometry imaging (MSI), were reviewed. Derivatization methods and optimal reaction conditions commonly used according to
different mass spectrometry analysis methods were summarized. The future development direction of mass spectrometry analysis
of fatty acids was prospected to provide reference and guidance for related research in forensic science（62 ref. cited）.
Keywords: derivatization; analysis; fatty acid; mass spectrometry

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